Surrogate-based Optimization for Pharmaceutical Manufacturing Processes
09 Jun 2023 | Contributor(s):: Wang, Zilong, Escotet-Espinoza, M Sebastian Singh, Ravendra, Ierapetritou, Marianthi
The development of pharmaceutical manufacturing processes has been facilitated by recent advances in the process simulation area. However, since the simulations are usually complex and the analytical expressions of the model can be unknown, it is difficult to directly apply traditional...
A hybrid neural network-first principles approach to process modeling
09 Jun 2023 | Contributor(s):: Psichogios, Dimitris C., Ungar, Lyle H.
A hybrid neural networkâ€first principles modeling scheme is developed and used to model a fedbatch bioreactor. The hybrid model combines a partial first principles model, which incorporates the available prior knowledge about the process being modeled, with a neural network which...