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Demonstrating scalability between two blender types using DEM
Peer-reviewed journal | 12 Nov 2024 | Contributor(s):: Peter Boehling, Johan Remmelgas, Mohammadsadegh Salehi, Johannes Poms, Rúben Martins Fraga, Manel Bautista, Johannes G. Khinast, Emmanuela Gavi, Michela Beretta
Powder blending is a critical step in pharmaceutical manufacturing that can impact product quality such as tablet tensile strength. This study utilized the Discrete Element Method (DEM) to investigate blending in a 5-liter mini-batch and a 2-liter Turbula blender. DEM parameters were calibrated...
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Improvement of a pharmaceutical powder mixing process in a tote blender via DEM simulations
Peer-reviewed journal | 04 Jun 2024 | Contributor(s):: Benedict Benque, Luca Orefice, Thomas Forgber, Matthias Habeler, Beate Schmid, Johan Remmelgas, Johannes Khinast
An industrial-scale pharmaceutical powder blending process was studied via discrete element method (DEM) simulations. A DEM model of two active pharmaceutical ingredient (API) components and a combined excipient component was calibrated by matching the simulated response in a dynamic angle of...
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A modified Kushner-Moore approach to characterising small-scale blender performance impact on tablet compaction
Peer-reviewed journal | 03 Jun 2024 | Contributor(s):: Hikaru G. Jolliffe, Martin Prostredny, Carlota Mendez Torrecillas, Ecaterina Bordos, Collette Tierney, Ebenezer Ojo, Richard Elkes, Gavin Reynolds, Yunfei Li Song, Bernhard Meir, Sara Fathollahi, John Robertson
Continuous Direct Compaction (CDC) has emerged as a promising route towards producing solid dosage forms while reducing material, development time and energy consumption. Understanding the response of powder processing unit operations, especially blenders, is crucial. There is a substantial body...
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Multi-dimensional population balance modeling and experimental validation of continuous powder mixing processes
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, Maitraye, Singh, Ravendra Vanarase, Aditya John, Joyce, Ramachandran, Rohit
It has been recognized that the application of quality by design (QbD) to continuous processing in the pharmaceutical industry leads to better process control, improved product quality and mitigates scale-up issues (Schaber et al., 2011), whereby a component of QbD involves the development...
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Mathematical development and comparison of a hybrid PBM-DEM description of a continuous powder mixing process
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, Maitraye, Dubey, Atul Singh, Ravendra, Ramachandran, Rohit
This paper describes the development of a multidimensional population balance model (PBM) which can account for the dynamics of a continuous powder mixing/blending process. The PBM can incorporate the important design and process conditions and determine their effects on the various critical...