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  1. Effect of High Shear Blending Protocols and Blender Parameters on the Degree of API Agglomeration in Solid Formulations

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    Contributor(s):: Llusa, M, Sturm, K, Sudah, O, Stamato, H, Goldfarb, DJ, Ramachandruni, H, Hammond, S, Smith, MR, Muzzio, FJ

    This paper examines the effect of three protocols with several units and blender parameters on the mitigation of active pharmaceutical ingredient (API) agglomeration in solid formulations. The three protocols either preblend API with a portion of excipients in a high shear unit followed by...