Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity-A Review
Contributor(s):: Jakubowska, E, Ciepluch, N
Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend...