Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir
Contributor(s):: Keutz, Timo von, Williams, Jason D., Kappe, C. Oliver
In a rapidly changing environment, such as the current COVID-19 pandemic, continuous flow reactors bear the potential to increase the production of urgently needed active pharmaceutical ingredients (APIs) on demand. In the synthesis of remdesivir, the organometallic C-glycosylation step was...