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1. Mechanistic investigation of a Ru-catalyzed direct asymmetric reductive amination reaction for a batch or continuous process scale-up: an industrial perspective

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   09 Jun 2023 | Contributor(s):: Changi, SM, Yokozawa, TYamamoto, T, Nakajima, H, Embry, MC, Vaid, R, Luciani, CV, Wong, SW, Johnson, M, Moher, ED

   A comprehensive assessment of a Ru-catalyzed direct asymmetric reductive amination (DARA) reaction for producing an intermediate for an active pharmaceutical ingredient (API) was carried out. Experiments were conducted to investigate the impact of process parameters (such as reaction temperature,...

2. Continuous manufacturing – the Green Chemistry promise?

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   09 Jun 2023 | Contributor(s):: Klavs F. Jensen

   Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green...