Mechanistic investigation of a Ru-catalyzed direct asymmetric reductive amination reaction for a batch or continuous process scale-up: an industrial perspective
Contributor(s):: Changi, SM, Yokozawa, TYamamoto, T, Nakajima, H, Embry, MC, Vaid, R, Luciani, CV, Wong, SW, Johnson, M, Moher, ED
A comprehensive assessment of a Ru-catalyzed direct asymmetric reductive amination (DARA) reaction for producing an intermediate for an active pharmaceutical ingredient (API) was carried out. Experiments were conducted to investigate the impact of process parameters (such as reaction temperature,...