Development and Scale-Up of a Continuous Aerobic Oxidative Chan-am Coupling
Contributor(s):: Brewer, AC, Hoffman, PCMartinelli, JR, Kobierski, ME, Mullane, N, Robbins, D
Despite the benefits of high atom economy and low cost, aerobic oxidations have found limited use in the synthesis of active pharmaceutical ingredients (APIs) because of safety concerns and poor selectivity. In this report, the design, development, and scale-up of a continuous, high pressure...