Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy
09 Jun 2023 | Contributor(s):: Vanarase, Aditya, Alcalà, Manel, Jerez-Rozo, Jackeline, Muzzio, Fernando, Romañach, Rodolfo
A non-destructive NIR spectroscopic method was used to acquire on-line spectra of a continuous mixing process, and evaluate the performance of this novel system. Partial least squares (PLS) calibration models were developed and used for real-time determination of active ingredient concentration...
Oscillatory Flow Reactors (OFRs) for Continuous Manufacturing and Crystallization
09 Jun 2023 | Contributor(s):: McGlone, Thomas, Briggs, Naomi E. B., Clark, Catriona A., Brown, Cameron J., Sefcik, Jan, Florence, Alastair J.
Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow...