Resources (1-2 of 2)

1. Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications

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   09 Jun 2023 | Contributor(s):: Wood, Barbara, Girard, Kevin, Polster, Christopher, Croker, Denise

   Continuous crystallization has gained interest in the pharmaceutical sector as part of the drive toward thetransition from exclusive batch manufacturing to integrated continuous manufacturing in this industry. As a result, the design and operation of continuous crystallization processes for the...

2. Process modelling, design and technoeconomic evaluation for continuous paracetamol crystallisation

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   09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI

   Continuous Pharmaceutical Manufacturing (CPM) has a strong potential to catalyse pharmaceutical innovation. This paper analyses Continuous Oscillatory Baffled Crystalliser (COBC) optimal design and performance for paracetamol crystallisation, via systematic modelling and nonlinear optimization...