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PAT-based design of agrochemical co-crystallization processes: A case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-toluenesulfonamideitriphenylphosphine oxide
Contributor(s):: Powell, KA, Croker, DMRielly, CD, Nagy, ZK
In this study, the selective crystallization and characterization of the stoichiometric forms of the p-to-luenesulfonamide/triphenylphosphine oxide (p-TSA-TPPO) co-crystal system in acetonitrile (MeCN) is demonstrated using batch and semi-batch crystallizers. In the batch study, both 1:1 and 3:2...
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Crystallisation and physicochemical property characterisation of conformationally-locked co-crystals of fenamic acid derivatives
Contributor(s):: Wittering, KE, Agnew, LRKlapwijk, AR, Robertson, K, Cousen, AJP, Cruickshank, DL, Wilson, CC
Polymorphism in drug compounds can cause significant problems for industrial-scale production and so a method for restricting the conformational freedom of the target compound whilst retaining desired chemical properties is highly beneficial to the pharmaceutical industry. Co-crystallisation is...
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Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century
Contributor(s):: Tiwari, RV, Patil, H, Repka, MA
Introduction: Hot-melt extrusion (HME) technology is applied successfully in the plastic, rubber and food industry. HME has also emerged as an important technology for drug delivery applications in pharmaceutical Research Article and manufacturing because of its process automation and low-cost...