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Tags: continuous

Resources (1-11 of 11)

  1. Twin Screw Granulation: Effects of Properties of Primary Powders

    09 Jun 2023 | Contributor(s):: Lute, Sushma, V, Dhenge, Ranjit M., Salman, Agba D.

    Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited Research Article published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders...

  2. Twin-screw granulation and high-shear granulation: The influence of mannitol grade on granule and tablet properties

    09 Jun 2023 | Contributor(s):: Megarry, Andrew, Taylor, Agnes, Gholami, Aida, Wikstrom, Hakan, Tajarobi, Pirjo

    Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of input grade has been shown to impact granule properties....

  3. Robust State Estimation of Feeding-Blending Systems in Continuous Pharmaceutical Manufacturing

    09 Jun 2023 | Contributor(s):: Liu, Jianfeng, Su, Qinglin, Moreno, Mariana, Laird, Carl, Nagy, Zoltan, Reklaitis, Gintaras

    State estimation is a fundamental part of monitoring, control, and real-time optimization in continuous pharmaceutical manufacturing. For nonlinear dynamic systems with hard constraints, moving horizon estimation (MHE) can estimate the current state by solving a well-defined optimization problem...

  4. Multi-dimensional population balance modeling and experimental validation of continuous powder mixing processes

    09 Jun 2023 | Contributor(s):: Sen, Maitraye, Singh, Ravendra Vanarase, Aditya John, Joyce, Ramachandran, Rohit

    It has been recognized that the application of quality by design (QbD) to continuous processing in the pharmaceutical industry leads to better process control, improved product quality and mitigates scale-up issues (Schaber et al., 2011), whereby a component of QbD involves the development...

  5. Mechanistic modeling for systematic design and analysis of PAT systems

    09 Jun 2023 | Contributor(s):: Singh, Ravendra, Samad, Noor Asma Fazli Abdul Gernaey, Krist V Woodley, John M, Gani, Rafiqul

    Not available

  6. Mathematical development and comparison of a hybrid PBM-DEM description of a continuous powder mixing process

    09 Jun 2023 | Contributor(s):: Sen, Maitraye, Dubey, Atul Singh, Ravendra, Ramachandran, Rohit

    This paper describes the development of a multidimensional population balance model (PBM) which can account for the dynamics of a continuous powder mixing/blending process. The PBM can incorporate the important design and process conditions and determine their effects on the various critical...

  7. Characterization of NIR interfaces for the feeding and in-line monitoring of a continuous granulation process

    09 Jun 2023 | Contributor(s):: Román-Ospino, Andrés D, Tamrakar, Ashutosh Igne, Benoît Dimaso, Elyse Towns Airiau, Christian Clancy, Donald J Pereira, Glinka Muzzio, Fernando J Singh, Ravendra, Ramachandran, Rohit

    This work describes the characterization of three NIR interfaces intended to monitor a continuous granulation process. Two interfaces (i.e. a barrel interface and a rotating paddle interface) were evaluated to monitor the API concentration at the entrance of the granulator, and a third interface...

  8. Advanced methodologies for cocrystal synthesis

    09 Jun 2023 | Contributor(s):: Douroumis, D, Ross, SA, Nokhodchi, A

    Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties...

  9. Achieving continuous manufacturing in lyophilization: Technologies and approaches

    09 Jun 2023 | Contributor(s):: Pisano, Roberto, Arsiccio, Andrea, Capozzi, Luigi C., Trout, Bernhardt L.

    This paper provides an organic overview of the most interesting continuous freeze-drying concepts that have been proposed over the years. Attention has mainly been focused on the field of pharmaceuticals, but some background has also been given on the food industry. This work aims at providing a...

  10. Advanced Control of Continuous Pharmaceutical Tablet Manufacturing Processes

    09 Jun 2023 | Contributor(s):: Singh, Ravendra, Velazquez, Carlos Sahay, Abhishek Karry, Krizia M Muzzio, Fernando J Ierapetritou, Marianthi G, Ramachandran, Rohit

    A novel manufacturing strategy based on continuous processing, integrated with online/inline monitoring tools, coupled with an advanced automatic feedback control system is highly desired for efficient Quality by Design (QbD)-based manufacturing of the next generation of pharmaceutical products...

  11. A Systematic Framework for the Design and Implementation of Sensing and Control Architecture for a Continuous Pharmaceutical Manufacturing Plant

    09 Jun 2023 | Contributor(s):: Singh, Ravendra, Muzzio, Fernando J Ierapetritou, Marianthi, Ramachnadran, Rohit

    The continuous pharmaceutical manufacture (CPM) plant and control architecture developed earlier is currently being widely implemented in industries [1,2]. CPM indeed provides an appropriate platform to implement suitable monitoring and control architecture, to improve product quality, and to...