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1. Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform with full recycle and minimal material use

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   Peer-reviewed journal | 05 Sep 2024 | Contributor(s):: Wei-Lee Wu, Zoltan K. Nagy, Yash Barhate, Hemalatha Kilari

   A systematic digital design framework for the development of a digital twin of a continuous crystallization process was presented using the model compound, diphenhydramine hydrochloride (DPH). The key features of the framework include operating space investigations, kinetic parameter estimation...

2. Pharmaceutical crystallisation processes from batch to continuous operation using MSMPR stages: Modelling, design, and control

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Su, Qinglin, Nagy, Zoltan K., Rielly, Chris D.

   In pharmaceuticals manufacturing, the conversion of conventional batch crystallisations to continuous mode has the potential for intensified, compact operation and more consistent production via quality-by-design. A pragmatic conversion approach is to utilise existing stirred tank batch...

3. Advanced control of a continuous oscillatory flow crystalliser

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Tahir, F, Krzemieniewska-Nandwani, KMack, J, Lovett, D, Siddique, H, Mabbott, F, Raval, V, Houson, I, Florence, A

   This paper presents the application and challenges of achieving Model Predictive Control (MPC) on two continuous oscillatory baffled crystallisation reactors, delivering precise product quality control in the face of raw material fluctuations. A key advantage of MPC is that it effectively deals...