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USP Excipients Workshop: Understanding the Impact of Material Attributes on Product Quality for Continuous Manufacturing (On-Demand)
| Contributor(s):: Thomas O’Connor
For continuous manufacturing processes, the impact of variation in material attributes on material feeding and process dynamics should be characterized and appropriate controls implemented if needed.
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Development of a Controlled Continuous Low-Dose Feeding Process
| Contributor(s):: Fathollahi, Sara, Kruisz, Julia, Sacher, Stephan, Rehrl, Jakob, Escotet-Espinoza, M. Sebastian, DiNunzio, James, Glasser, Benjamin J., Khinast, Johannes G.
This paper proposes a feed rate control strategy for a novel volumetric micro-feeder, which can accomplish low-dose feeding of pharmaceutical raw materials with significantly different powder properties. The developed feed-forward control strategy enables a constant feed rate with a minimum...
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Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders
| Contributor(s):: Sacher, S, Fathollahi, S, Khinast, JG
Purpose Accurate and reliable feeding of small quantities of powder is crucial in many industries. It is particularly true in the case of pharmaceutical manufacturing. First, the exact dosage of highly potent active pharmaceutical ingredients (APIs) is essential. Second, due to the shift towards...
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A solution for low-dose feeding in continuous pharmaceutical processes
| Contributor(s):: Sacher, S, Heindl, NUrich, JAA, Kruisz, J, Khinast, JG
Continuous feeding of small quantities of powder is increasingly applied in pharmaceutical manufacturing. With that regard, what is crucial is not only the feasibility, but also the accuracy and stability. To enable stable processing, low amounts of various agents, e.g., lubricants, can be used....