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1. Understanding Powder Behavior in Continuous Feeding: Powder Densification and Screw Layering

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   Peer-reviewed journal | 16 Oct 2024 | Contributor(s):: Sara Fathollahi, Pauline H. M. Janssen, Bram Bekaert, Dirk Vanderroost, Valerie Vanhoorne, Bastiaan H. J. Dickhoff

   Background: Precise continuous feeding of active pharmaceutical ingredients (APIs) and excipients is crucial in a continuous powder-to-tablet manufacturing setup, as any inconsistency can affect the final tablet quality. Method: This study investigated the impact of various materials on the...

2. USP Excipients Workshop: Understanding the Impact of Material Attributes on Product Quality for Continuous Manufacturing (On-Demand)

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   Seminars | 31 Jan 2024 | Contributor(s):: Thomas O’Connor

   For continuous manufacturing processes, the impact of variation in material attributes on material feeding and process dynamics should be characterized and appropriate controls implemented if needed.

3. Development of a Controlled Continuous Low-Dose Feeding Process

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Fathollahi, Sara, Kruisz, Julia, Sacher, Stephan, Rehrl, Jakob, Escotet-Espinoza, M. Sebastian, DiNunzio, James, Glasser, Benjamin J., Khinast, Johannes G.

   This paper proposes a feed rate control strategy for a novel volumetric micro-feeder, which can accomplish low-dose feeding of pharmaceutical raw materials with significantly different powder properties. The developed feed-forward control strategy enables a constant feed rate with a minimum...

4. Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sacher, S, Fathollahi, S, Khinast, JG

   Purpose Accurate and reliable feeding of small quantities of powder is crucial in many industries. It is particularly true in the case of pharmaceutical manufacturing. First, the exact dosage of highly potent active pharmaceutical ingredients (APIs) is essential. Second, due to the shift towards...

5. A solution for low-dose feeding in continuous pharmaceutical processes

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sacher, S, Heindl, NUrich, JAA, Kruisz, J, Khinast, JG

   Continuous feeding of small quantities of powder is increasingly applied in pharmaceutical manufacturing. With that regard, what is crucial is not only the feasibility, but also the accuracy and stability. To enable stable processing, low amounts of various agents, e.g., lubricants, can be used....