The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds
Contributor(s):: Bana, P, Orkenyi, RLovei, K, Lako, A, Turos, GI, Eles, J, Faigl, F, Greiner, I
Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing...
Continuous purification of active pharmaceutical ingredients using multistage organic solvent nanofiltration membrane cascade
Contributor(s):: Peeva, L, Burgal, JDValtcheva, I, Livingston, AG
Downstream processing accounts for a large fraction of the production costs in pharmaceutical manufacturing. Organic solvent nanofiltration performed in a membrane cascade offers an interesting possibility for a continuous downstream processing unit operation. This work demonstrates continuous...