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Continuous Manufacturing: Many Want It, But Here's Why Few Have It
| Contributor(s):: Ioanna Deni
Continuous manufacturing remains a key objective among bioprocessing professionals. While continuous bioprocessing isn’t a new concept, having been applied in the production of both old and new products, significant technological advancements set the stage for its wider adoption.
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The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds
| Contributor(s):: Bana, P, Orkenyi, RLovei, K, Lako, A, Turos, GI, Eles, J, Faigl, F, Greiner, I
Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing...
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Continuous purification of active pharmaceutical ingredients using multistage organic solvent nanofiltration membrane cascade
| Contributor(s):: Peeva, L, Burgal, JDValtcheva, I, Livingston, AG
Downstream processing accounts for a large fraction of the production costs in pharmaceutical manufacturing. Organic solvent nanofiltration performed in a membrane cascade offers an interesting possibility for a continuous downstream processing unit operation. This work demonstrates continuous...