All Categories (1-5 of 5)

1. Drying capacity of a continuous vibrated fluid bed dryer – Statistical and mechanistic model development

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   Peer-reviewed journal | 14 Sep 2023 | Contributor(s):: Johan Remmelgas, Robin Meier, Andreas Altmeyer, Daniel Emanuele, Miika Jormanainen, Anne Juppo, Pirjo Tajarobi, Luis Martin de Juan, Håkan Wikström

   The drying capacity of a continuous vibrated fluid bed dryer was studied using a DoE by varying microcrystalline cellulose content in the formulation, water amount in the twin-screw granulation, inlet air temperature, air flow rate and the acceleration of the horizontal fluid-bed....

2. Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Liu, Huolong, Galbraith, S. C., Ricart, Brendon, Stanton, Courtney, Smith-Goettler, Brandye, Verdi, Luke, O'Connor, Thomas, Lee, Sau, Yoon, Seongkyu

   In this study, the influence of key process variables (screw speed, throughput and liquid to solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using a central composite face-centered (CCF) experimental design method. Regression models were developed to predict...

3. Indirect monitoring of ultralow dose API content in continuous wet granulation and tableting by machine vision

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Ficzere, Máté, Mészáros, Lilla Alexandra, Madarász, Lajos, Novák, Márk, Nagy, Zsombor Kristóf, Galata, Dorián László

   This paper presents new machine vision–based methods for indirect real-time quantification of ultralow drug content during continuous twin-screw wet granulation and tableting. Granulation was performed with a solution containing carvedilol (CAR) as API in the ultralow dose range (0.05 w/w% in the...

4. Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Willecke, N., Szepes, A., Wunderlich, M., Remon, J. P., Vervaet, C., De Beer, T.

   The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be used for a Quality by Design (QbD)-based formulation...

5. A novel approach to support formulation design on twin screw wet granulation technology: Understanding the impact of overarching excipient properties on drug product quality attributes

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Willecke, N., Szepes, A., Wunderlich, M., Remon, J. P., Vervaet, C., De Beer, T.

   The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based...