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Tags: Control concept

Resources (1-2 of 2)

  1. PAT implementation for advanced process control in solid dosage manufacturing - A practical guide

    09 Jun 2023 | Contributor(s):: Sacher, Stephan, Poms, Johannes, Rehrl, Jakob, Khinast, Johannes G.

    The implementation of continuous pharmaceutical manufacturing requires advanced control strategies rather than traditional end product testing or an operation within a small range of controlled parameters. A high level of automation based on process models and hierarchical control concepts is...

  2. Automated and continuous synthesis of drug substances

    09 Jun 2023 | Contributor(s):: Sacher, Stephan, Castillo, Ismael, Rehrla, Jakob, Sagmeistera, Peter, Lebl, René, Kruisza, Julia, Celikovic, Selma, Sipek, Martin, Williams, Jason D, Kirschneck, Dirk, Kappea, C. Oliver, Horn, Martin

    A continuous synthesis line was developed integrating different common reaction stepsnamely nitration, substitution and hydrogenation. Mesalazine as model drug substancewas produced from 2-chlorobenzoic acid in continuous flow mode. A multi-instrument PATstrategy was implemented to equip the full...