Skip to main content
3.137.187.71

Tags: Controlled release

All Categories (1-6 of 6)

  1. Rolling phenomenon in twin screw granulation with controlled-release excipients

    Contributor(s):: Thompson, M. R., O'Donnell, K. P.

    The developed knowledge regarding use of twin screw granulators for continuous wet granulation has been primarily limited to immediate release formulations in the literature. The present study highlights an issue previously unreported for wet granulation with twin screw extruders when using...

  2. Low Energy Nanoemulsions as Templates for the Formulation of Hydrophobic Drugs

    Contributor(s):: Badruddoza, AM, Gupta, AMyerson, AS, Trout, BL, Doyle, PS

    Most small molecule active pharmaceutical ingredients (APIs) are hydrophobic which poses formulation challenges due to their poor water solubility. Current approaches are energy intensive and involve presenting the API in a nanoparticle form that is then combined with other additives into a...

  3. Hypromellose - A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery

    Contributor(s):: Maskova, Eliska, Kubova, Katerina, Raimi-Abraham, Bahijja T., Vllasaliu, Driton, Vohlidalova, Eva, Turanek, Jaroslav, Masek, Josef

    Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great...

  4. Future Supply Chains Enabled by Continuous Processing - Opportunities and Challenges

    Contributor(s):: Jagjit Singh Srai, Markus Krumme, Mauricio Futran, Clive Badman, Craig Johnston

    This paper examines the opportunities and challenges facing the pharmaceutical industry in moving to a primarily “continuous processing”-based supply chain. The current predominantly “large batch” and centralized manufacturing system designed for the “blockbuster” drug has driven a slow-paced,...

  5. Characterization of a novel hydroxypropyl methylcellulose (HPMC) direct compression grade excipient for pharmaceutical tablets

    Contributor(s):: Allenspach, Carl, Timmins, Peter, Sharif, Shasad, Minko, Tamara

    Controlled release tablets are important dosage forms enabling a slower release of the drug and better pharmacokinetics for some drugs and hydrophilic matrix tablets utilizing hydroxypropyl methylcellulose (HPMC) are one of the most common types. One of the main challenges with using HPMC is its...

  6. A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing

    Contributor(s):: Nashed, Nour, Lam, Matthew, Nokhodchi, Ali

    Oral dosage formulations are considered to be the most convenient pharmaceutical dosage forms for almost all ages because of their simplicity and non-invasive administration compared to other dosage forms. To improve therapeutic efficacy and avoid frequent daily doses, extending drug release...