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The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals
Contributor(s):: Weber, CC, Kulkarni, SAKunov-Kruse, AJ, Rogers, RD, Myerson, AS
The application of ionic liquids (ILs) as solvents is frequently discussed in the context of their tunability, with the potential to tailor the solvent system uniquely to the process being investigated. Instead, here we study the potential for a single IL, 1-ethyl-3-methylimidazohum...
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Population Balance Model Development Verification and Validation of Cooling Crystallization of Carbamazepine
Contributor(s):: Liu, Yiqing C., Acevedo, David Yang, Xiaochuan Naimi, Sean, Wu, Wei-Lee, Pavurala, Naresh, Nagy, Zoltan K., O'Connor, Thomas F.
Using process modeling to understand process dynamics and potentially explore the design space of a crystallization process is difficult because of its complex nature with many factors at play, such as initial concentration, supersaturation, seeding strategy, and flow pattern. In this work, a...
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Development of continuous crystallization processes using a single-stage mixed-suspension, mixed-product removal crystallizer with recycle
Contributor(s):: Wong, Shin Yee, Tatusko, Adam P. Trout, Bernhardt L., Myerson, Allan S. ;
An ideal pharmaceutical crystallization process produces a pure product at a high yield while minimizing energy input, the process equipment footprint, and its complexity. A good candidate for such a process is a single-stage mixed-suspension, mixed-product removal (MSMPR) crystallizer with...
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Crystal Size Control in a Continuous Tubular Crystallizer
Contributor(s):: Besenhard, Maximilian O., Neugebauer, Peter Ho, Cheng-Da, Khinast, Johannes G.
This paper describes a simple model-free (i.e., empirical) control strategy for crystal size tuning in a continuously operated tubular crystallizer. The crystallizer is designed for a seeded cooling crystallization process and acetylsalicylic acid crystallization from an ethanol solution was used...