Resources (1-3 of 3)

1. Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed Crystallization and Fluidized Bed Processing

   0.0 out of 5 stars 

   09 Jun 2023 | Contributor(s):: Stocker, MW, Harding, MJTodaro, V, Healy, AM, Ferguson, S

   Integrated API and drug product processing enable molecules with high clinical efficacy but poor physicochemical characteristics to be commercialized by direct co-processing with excipients to produce advanced multicomponent intermediates. Furthermore, developing isolation-free frameworks would...

2. Development of directly compressible powders via co-spray drying

   0.0 out of 5 stars 

   09 Jun 2023 | Contributor(s):: Gonnissen, Y., Remon, J. P., Vervaet, C.

   Continuous production of directly compressible powders was achieved by coprocessing acetaminophen and carbohydrates via spray drying. Binary and ternary powder mixtures containing drug substance and carbohydrates were prepared by co-spray drying and evaluated on spray drying processibility,...

3. Continuous manufacturing of delta mannitol by cospray drying with PVP

   0.0 out of 5 stars 

   09 Jun 2023 | Contributor(s):: Vanhoorne, V., Van Bockstal, P-J., Van Snick, B., Peeters, E., Monteyne, T., Gomes, P., De Beer, T., Remon, J. P., Vervaet, C.

   Mannitol is a frequently used diluent in the production of tablets due to its non-hygroscopic character and low drug interaction potential. Although the delta-polymorph of mannitol has superior tabletability in comparison to alpha- and beta-mannitol, the latter are most commonly used because...