Continuous-flow tubular crystallization in slugs spontaneously induced by hydrodynamics
09 Jun 2023 | Contributor(s):: Jiang, Mo, Zhu, Zhilong Jimenez, Ernesto Papageorgiou, Charles D., Waetzig, Josh, Hardy, Andrew, Langston, Marianne, Braatz, Richard D.
A novel continuous crystallizer design is described with the potential to provide improved control of crystal properties, improved process reproducibility, and reduced scale-up risk. Liquid and gas are introduced into one end of the tube at flow rates selected to spontaneously generate...
A design aid for crystal growth engineering
09 Jun 2023 | Contributor(s):: Li, Jinjin, Tilbury, Carl J. Kim, Seung Ha, Doherty, Michael F.
With the highly competitive development of chemical and pharmaceutical industries, mastering crystal growth is becoming increasingly necessary. Modern industrial manufacturers place high importance on the ability to grow crystals with a specific habit using tailored operating conditions. A...