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1. Process modelling, design and technoeconomic evaluation for continuous paracetamol crystallisation

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   09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI

   Continuous Pharmaceutical Manufacturing (CPM) has a strong potential to catalyse pharmaceutical innovation. This paper analyses Continuous Oscillatory Baffled Crystalliser (COBC) optimal design and performance for paracetamol crystallisation, via systematic modelling and nonlinear optimization...

2. From form to function: Crystallization of active pharmaceutical ingredients

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   09 Jun 2023 | Contributor(s):: Variankaval, Narayan, Cote, Aaron S., Doherty, Michael F.

   In this perspective, we describe the state-of-the-art in API crystal product and process design, highlight barriers that currently prevent the production of better, cheaper crystalline products, and give our best estimate of where the field is going and should go during the next decade.