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1. The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

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   09 Jun 2023 | Contributor(s):: Nguyen, TTH, Khan, ABruce, LM, Forbes, C, O'Leary, RL, Price, CJ

   Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield) and crystal properties (crystal size...

2. Tailoring the crystal size distribution of an active pharmaceutical ingredient by continuous antisolvent crystallization in a planar oscillatory flow crystallizer

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   09 Jun 2023 | Contributor(s):: Cruz, P, Alvarez, CRocha, F, Ferreira, A

   An active pharmaceutical ingredient is currently produced in a traditional batch antisolvent crystallization process. Although well-established, this process lacks flexibility to control the crystal size distribution (CSD). Therefore, a new process was developed to enable the control of the CSD...

3. Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry

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   09 Jun 2023 | Contributor(s):: Gao, Zhenguo, Gong, Junbo, Rohani, Sohrab, Wang, Jingkang

   Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in...

4. Control of Batch and Continuous Crystallization Processes using Reinforcement Learning

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   09 Jun 2023 | Contributor(s):: Benyahia, Brahim, Anandan, Paul Danny Rielly, Chris Türkay, Metin, Gani, Rafiqul

   In crystallization processes, the control of particle size distribution, shape and purity are crucial to achieve the targeted critical quality attributes of the final drug product and meet the pharmaceutical regulatory requirements. This work presents novel optimal trajectory tracking control...

5. Continuous Pharmaceutical Crystallization from Solution

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   09 Jun 2023 | Contributor(s):: Price, CJ

   Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing