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1. Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones

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   09 Jun 2023 | Contributor(s):: Tanimura, Shinji, Singh, Ravendra Román-Ospino, Andrés D, Ierapetritou, Marianthi

   The presence of a ‘significant dead zone’ in any continuous manufacturing equipment may affect the product quality and need to be investigated systematically. Dead zone will affect the residence time distribution (RTD) of continuous manufacturing and thus the mixing and product quality. Tablet...

2. Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes

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   09 Jun 2023 | Contributor(s):: Peterwitz, Moritz, Gerling, Sina, Schembecker, Gerhard

   Loss-in-weight feeders are an integral part of most continuous manufacturing processes, ensuring a constant mass flow. The feeders cause a significant degree of back-mixing in such lines. Understanding back-mixing is essential for the treatment of disturbances. However, feeders refilled...