All Categories (1-3 of 3)

1. Improvement of a pharmaceutical powder mixing process in a tote blender via DEM simulations

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   | Contributor(s):: Benedict Benque, Luca Orefice, Thomas Forgber, Matthias Habeler, Beate Schmid, Johan Remmelgas, Johannes Khinast

   An industrial-scale pharmaceutical powder blending process was studied via discrete element method (DEM) simulations. A DEM model of two active pharmaceutical ingredient (API) components and a combined excipient component was calibrated by matching the simulated response in a dynamic angle of...

2. The Effect of Mixer Properties and Fill Level on Granular Flow in a Bladed Mixer

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   | Contributor(s):: Remy, B, Glasser, BJ, Khinast, JG

   The discrete element method was used to study the effect of mixer properties and fill level oil the granular flow of monodisperse, cohesionless spheres in a bladed mixer. For fill levels just covering the span of the blades, a three-dimensional (3-D) recirculation zone develops in front of the...

3. Mathematical development and comparison of a hybrid PBM-DEM description of a continuous powder mixing process

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   | Contributor(s):: Sen, Maitraye, Dubey, Atul Singh, Ravendra, Ramachandran, Rohit

   This paper describes the development of a multidimensional population balance model (PBM) which can account for the dynamics of a continuous powder mixing/blending process. The PBM can incorporate the important design and process conditions and determine their effects on the various critical...