Roller compaction: Infrared thermography as a PAT for monitoring powder flow from feeding to compaction zone
09 Jun 2023 | Contributor(s):: Yu, Mingzhe, Omar, Chalak, Weidemann, Marcus, Schmidt, Alexander, Litster, James D., Salman, Agba D.
Roller compaction is a continuous dry granulation process, in which powder is compressed by two counter-rotating rollers. During this process, the powder feeding to the compaction zone has a significant effect on product quality. This work investigates the flow of powder from the feeding zone to...
Evaluation of three approaches for real-time monitoring of roller compaction with near-infrared spectroscopy
09 Jun 2023 | Contributor(s):: Acevedo, D., Muliadi, A., Giridhar, A., Litster, J. D., Romañach, R. J.
Three different approaches have been evaluated for monitoring ribbon density through real-time near-infrared spectroscopy measurements. The roll compactor was operated to produce microcrystalline cellulose (MCC) ribbons of varying densities. The first approach used the slope of the spectra which...