Application of Continuous Flow in Tazobactam Synthesis
Contributor(s):: Zhou, Shuhao, Xin, Yunting, Wang, Jiasheng, Wu, Chengjun, Sun, Tiemin
Tazobactam is a β-lactamase inhibitor. In this work, a combination of continuous flow and batch experiments for the synthesis of tazobactam has been developed. The first three steps and the preparation of the peroxyacetic acid are continuously carried out in the microreactors, which improves the...