Model-based approach to the design of pharmaceutical roller-compaction processes
Contributor(s):: Toson, Peter, Lopes, Diogo G. Paus, Raphael Kumar, Ashish, Geens, Jeroen, Stibale, Sandy, Quodbach, Julian, Kleinebudde, Peter, Hsiao, Wen-Kai, Khinast, Johannes
This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput experiments as input. This low-throughput data is utilized in an...