Semicontinuous Process for GMP Manufacture of a Carbapenem Intermediate via Carbene Insertion Using an Immobilized Rhodium Catalyst
Contributor(s):: Gage, James R., Chen, Furong, Dong, Changming, Gonzalez, Miguel A., Jiang, Yong, Luo, Yong, McLaws, Mark D., Tao, Jian
A two-stage flow process for cGMP manufacture of a commercially important carbapenem intermediate was developed. Stage 1 featured an intramolecular N–H insertion reaction catalyzed by an immobilized rhodium catalyst. In stage 2, phosphorylation of the resulting keto ester intermediate afforded...