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Tags: dirhodium(II) immobilization

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  1. Semicontinuous Process for GMP Manufacture of a Carbapenem Intermediate via Carbene Insertion Using an Immobilized Rhodium Catalyst

    25 Jun 2024 | Contributor(s):: Gage, James R., Chen, Furong, Dong, Changming, Gonzalez, Miguel A., Jiang, Yong, Luo, Yong, McLaws, Mark D., Tao, Jian

    A two-stage flow process for cGMP manufacture of a commercially important carbapenem intermediate was developed. Stage 1 featured an intramolecular N–H insertion reaction catalyzed by an immobilized rhodium catalyst. In stage 2, phosphorylation of the resulting keto ester intermediate afforded...