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1. Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles

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   Contributor(s):: Han, Xi, Ghoroi, Chinmay, To, Daniel, Chen, Yuhua, Dave, Rajesh

   Simultaneous micronization and surface modification of drug particles is considered in order to mitigate disadvantages of micronization, e.g., agglomeration, poor flowability, marginal increase in surface area and low bulk density. Particles of ibuprofen (102 mu m), a model drug, pre-blended with...

2. Influence of process parameters and equipment on dry foam formulation properties using indomethacin as model drug

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   Contributor(s):: Sprunk, A, Page, S, Kleinebudde, P

   Dry foam technology was developed to overcome insufficient oral bioavailability of poorly soluble and wettable active pharmaceutical ingredients (APIs). It is intended to enable a faster and more efficient dissolution by avoiding API agglomeration and floating of non-wetted API particles. The aim...