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1. Synthesis of Dolutegravir Exploiting Continuous Flow Chemistry

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   10 May 2024 | Contributor(s):: Nqeketo, Sinazo, Watts, Paul

   An efficient continuous flow process for the synthesis of dolutegravir, an active pharmaceutical ingredient (API) for HIV treatment, was investigated. The synthetic procedure starts from a readily available benzyl-protected pyran via six chemical transformations using continuous flow reactors....