Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles
Contributor(s):: Han, Xi, Ghoroi, Chinmay, To, Daniel, Chen, Yuhua, Dave, Rajesh
Simultaneous micronization and surface modification of drug particles is considered in order to mitigate disadvantages of micronization, e.g., agglomeration, poor flowability, marginal increase in surface area and low bulk density. Particles of ibuprofen (102 mu m), a model drug, pre-blended with...
Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing suitability of different dry coating processes
Contributor(s):: Chen, Liang, He, Zizhou, Kunnath, Kuriakose, Zheng, Kai, Kim, Sangah, Dave, Rajesh N.
Recent work showed that contrary to conventional wisdom, fine surface engineered excipients outperform their larger counterparts in blends of highly loaded blends of cohesive drug powders in terms of their packing, flowability and tablet tensile strength. Here, two continuous devices, fluid...