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1. Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes

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   09 Jun 2023 | Contributor(s):: Peterwitz, Moritz, Gerling, Sina, Schembecker, Gerhard

   Loss-in-weight feeders are an integral part of most continuous manufacturing processes, ensuring a constant mass flow. The feeders cause a significant degree of back-mixing in such lines. Understanding back-mixing is essential for the treatment of disturbances. However, feeders refilled...

2. Anti-fouling control of plug-flow crystallization via heating and cooling cycle

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   09 Jun 2023 | Contributor(s):: Koswara, Andy, Nagy, Zoltan K.

   Plug-flow crystallization (PFC) is a promising continuous pharmaceutical crystallization process but is prone to fouling due to uncontrolled crystallization on the reactor surface (encrustation). This results in operational issues such as (1) flow blockage, (2) increased thermal resistance, and...