Optimization in seeded cooling crystallization: A parameter estimation and dynamic optimization study
Contributor(s):: Nowee, S. Mostafa, Abbas, Ali, Romagnoli, Jose A.
In this solution crystallization study, a population balance model that predicts the crystal size distribution (CSD) is used for targeting, by optimization, the product mean size and the coefficient of variation of the final CSD. The model is robust over a wide range of conditions and predicts...
Anti-fouling control of plug-flow crystallization via heating and cooling cycle
Contributor(s):: Koswara, Andy, Nagy, Zoltan K.
Plug-flow crystallization (PFC) is a promising continuous pharmaceutical crystallization process but is prone to fouling due to uncontrolled crystallization on the reactor surface (encrustation). This results in operational issues such as (1) flow blockage, (2) increased thermal resistance, and...