Peer-reviewed journal (1-1 of 1)

1. Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source

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   Contributor(s):: Kockinger, M, Hone, CAGutrnann, B, Hanselmann, P, Bersier, M, Torvisco, A, Kappe, CO

   The development of a scalable telescoped continuous flow procedure for difluoromethylation of a protected amino acid with fluoroform (CHF3, R-23) gas and subsequent high temperature deprotection to provide eflornithine, an important Active Pharmaceutical Ingredient (API), is described....