On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
Contributor(s):: Adamo, A, Beingessner, RLBehnam, M, Chen, J, Jamison, TF, Jensen, KF, Monbaliu, JCM, Myerson, AS, Revalor, EM, Snead, DR, Stelzer, T, Weeranoppanant, N, Wong, SY, Zhang, P
Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis...
End-to-end continuous manufacturing of conventional compressed tablets: From flow synthesis to tableting through integrated crystallization and filtration
Contributor(s):: Domokos, A, Nagy, BGyurkes, M, Farkas, A, Tacsi, K, Pataki, H, Liu, YC, Balogh, A, Firth, P, Szilagyi, B, Marosi, G, Nagy, ZK
An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time. The output reaction mixture of the flow synthesis of acetylsalicylic acid was crystallized continuously in a...