Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin
25 Jun 2024 | Contributor(s):: Pastre, Julio C., Murray, Philip R. D., Browne, Duncan L., Brancaglion, Guilherme A., Galaverna, Renan S., Pilli, Ronaldo A., Ley, Steven V.
An integrated batch and continuous flow process has been developed for the gram-scale synthesis of goniothalamin. The synthetic route hinges upon a telescoped continuous flow Grignard addition followed by an acylation reaction capable of delivering a racemic goniothalamin precursor (16) (20.9 g...