Continuous twin screw granulation: Influence of process variables on granule and tablet quality
09 Jun 2023 | Contributor(s):: Vercruysse, J., Diaz, D. Cordoba, Peeters, E., Fonteyne, M., Delaet, U., Van Assche, I., De Beer, T., Remon, J. P., Veryaet, C.
The aim of the current study was to screen theophylline (125 mg) tablets manufactured via twin screw granulation in order to improve process understanding and knowledge of process variables that determine granule and tablet quality. A premix of theophylline anhydrate, alpha-lactose monohydrate...
A quality by design approach to investigate the effect of mannitol and dicalcium phosphate qualities on roll compaction
09 Jun 2023 | Contributor(s):: Souihi, Nabil, Dumarey, Melanie, Wikstrom, Hakan, Tajarobi, Pirjo, Fransson, Magnus, Svensson, Olof, Josefson, Mats, Trygg, Johan
Roll compaction is a continuous process for solid dosage form manufacturing increasingly popular within pharmaceutical industry. Although roll compaction has become an established technique for dry granulation, the influence of material properties is still not fully understood. In this study, a...