Selective crystallization of the metastable α-form of L-glutamic acid using concentration feedback control
09 Jun 2023 | Contributor(s):: Kee, Nicholas C.S., Tan, Reginald B.H. Braatz, Richard D., Braatz, Richard D.
A systematic methodology is presented for the selective crystallization of the metastable form of a monotropic dimorph, L-glutamic acid, for batch cooling crystallization. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy coupled with chemometrics was used to...
Development and Characterization of a Single Stage Mixed-Suspension, Mixed-Product-Removal Crystallization Process with a Novel Transfer Unit
09 Jun 2023 | Contributor(s):: Hou, GY, Power, GBarrett, M, Glennon, B, Morris, G, Zhao, Y
A continuously operated single stage mixed-suspension, mixed-product-removal (MSMPR) crystallizer using intermittent withdrawal via a dip pipe with combined pressure/vacuum was successfully developed for the manufacture of active pharmaceutical ingredients. Approximately 5.8% of the total...
Continuous reactive crystallization of an API in PFR-CSTR cascade with in-line PATs
09 Jun 2023 | Contributor(s):: Hu, CT, Shores, BTDerech, RA, Testa, CJ, Hermant, P, Wu, W, Shvedova, K, Ramnath, A, Al, Ismaili, LQ, Su, QL, Sayin, R, Born, SC, Takizawa, B, O'Connor, TF, Yang, XC, Ramanujam, S, Mascia, S
The continuous reactive crystallization of an active pharmaceutical ingredient (API) in a plug flow reactor (PFR)-continuous stirred tank reactor (CSTR) cascade system with in-line PATs was developed and investigated. Residence time distribution (RTD) measurements of the PFR (stage 1), the CSTR...