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1. Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation

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   09 Jun 2023 | Contributor(s):: Weber, CC, Wood, GPFKunov-Kruse, AJ, Nmagu, DE, Trout, BL, Myerson, AS

   The removal of carboxylic acid impurities from amide targets has been accomplished through crystallization featuring a complexing agent in solution. The interaction between the complexing agents and impurities was examined using isothermal titration calorimetry and the free energy of association...

2. Novel Technique for Filtration Avoidance in Continuous Crystallization

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   09 Jun 2023 | Contributor(s):: Yazdanpanah, N, Ferguson, STMyerson, AS, Trout, BL

   Fouling and clogging of lines in both continuous crystallization and flow chemistry still present a challenge in designing continuous processes. This paper presents a proof of concept for a novel unit operation designed for purification and to eliminate the need for slurry handling in API...

3. Low Energy Nanoemulsions as Templates for the Formulation of Hydrophobic Drugs

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   09 Jun 2023 | Contributor(s):: Badruddoza, AM, Gupta, AMyerson, AS, Trout, BL, Doyle, PS

   Most small molecule active pharmaceutical ingredients (APIs) are hydrophobic which poses formulation challenges due to their poor water solubility. Current approaches are energy intensive and involve presenting the API in a nanoparticle form that is then combined with other additives into a...