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Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation
Contributor(s):: Weber, CC, Wood, GPFKunov-Kruse, AJ, Nmagu, DE, Trout, BL, Myerson, AS
The removal of carboxylic acid impurities from amide targets has been accomplished through crystallization featuring a complexing agent in solution. The interaction between the complexing agents and impurities was examined using isothermal titration calorimetry and the free energy of association...
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Novel Technique for Filtration Avoidance in Continuous Crystallization
Contributor(s):: Yazdanpanah, N, Ferguson, STMyerson, AS, Trout, BL
Fouling and clogging of lines in both continuous crystallization and flow chemistry still present a challenge in designing continuous processes. This paper presents a proof of concept for a novel unit operation designed for purification and to eliminate the need for slurry handling in API...
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Low Energy Nanoemulsions as Templates for the Formulation of Hydrophobic Drugs
Contributor(s):: Badruddoza, AM, Gupta, AMyerson, AS, Trout, BL, Doyle, PS
Most small molecule active pharmaceutical ingredients (APIs) are hydrophobic which poses formulation challenges due to their poor water solubility. Current approaches are energy intensive and involve presenting the API in a nanoparticle form that is then combined with other additives into a...