Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles
Contributor(s):: Han, Xi, Ghoroi, Chinmay, To, Daniel, Chen, Yuhua, Dave, Rajesh
Simultaneous micronization and surface modification of drug particles is considered in order to mitigate disadvantages of micronization, e.g., agglomeration, poor flowability, marginal increase in surface area and low bulk density. Particles of ibuprofen (102 mu m), a model drug, pre-blended with...
Direct compaction properties of Zingiberis Rhizoma extracted powders coated with various shell materials: Improvements and mechanism analysis
Contributor(s):: Li, Zhe, Zhou, Miaomiao, Wu, Fei, Shen, Lan, Lin, Xiao, Feng, Yi
Direct compaction (DC) attracts more and more attention for tablet manufacturing; however, its application in natural plant product (NPP) tablets is still extremely limited. In this study, 8 kinds of composite particles (CPs) based on the Zingiberis Rhizoma extracted powder (ZR) (a natural plant...