Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles
Contributor(s):: Han, Xi, Ghoroi, Chinmay, To, Daniel, Chen, Yuhua, Dave, Rajesh
Simultaneous micronization and surface modification of drug particles is considered in order to mitigate disadvantages of micronization, e.g., agglomeration, poor flowability, marginal increase in surface area and low bulk density. Particles of ibuprofen (102 mu m), a model drug, pre-blended with...