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1. Rolling phenomenon in twin screw granulation with controlled-release excipients

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   09 Jun 2023 | Contributor(s):: Thompson, M. R., O'Donnell, K. P.

   The developed knowledge regarding use of twin screw granulators for continuous wet granulation has been primarily limited to immediate release formulations in the literature. The present study highlights an issue previously unreported for wet granulation with twin screw extruders when using...

2. Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder

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   09 Jun 2023 | Contributor(s):: Li, H., Thompson, M. R., O'Donnell, K. P.

   The influence of active pharmaceutical ingredient (API) hydrophobicity on continuous wet granulation was studied in twin screw granulation utilizing foamed binder delivery. The APIs examined were caffeine, acetaminophen, ibuprofen and griseofulvin and the drug load was maintained constant at 15...