Scale-Up of a Continuous Manufacturing Process of Edaravone
Contributor(s):: Zhou, Shuhao, Hong, Qingxia, Mei, Wenliu, He, Yan, Wu, Chengjun, Sun, Tiemin
Edaravone belongs to a class of brain-protective agents, which can scavenge free radicals. To reduce impurities and improve the yield, a continuous flow production process of edaravone was developed. The synthesis is continuously carried out in two steps. The throughput can reach 11.328 kg/day...