Skip to main content
Join CMKC members for a complimentary virtual event on December 10, 11am ET: CM MythBusters: https://bit.ly/3YXJynA. This is a fantastic opportunity to connect, collaborate, and debunk common myths about continuous manufacturing!
18.191.192.109

Tags: gas-liquid transformations

All Categories (1-1 of 1)

  1. Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source

    09 Jun 2023 | Contributor(s):: Kockinger, M, Hone, CAGutrnann, B, Hanselmann, P, Bersier, M, Torvisco, A, Kappe, CO

    The development of a scalable telescoped continuous flow procedure for difluoromethylation of a protected amino acid with fluoroform (CHF3, R-23) gas and subsequent high temperature deprotection to provide eflornithine, an important Active Pharmaceutical Ingredient (API), is described....