Semi-continuous multi-step synthesis of lamivudine
10 May 2024 | Contributor(s):: Mandala, Devender, Chadaa, Sravanthi, Watts, Paul
We report the first continuous flow synthesis of lamivudine, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B. The key intermediate (5-acetoxy oxathiolane) was prepared by an integrated two step continuous flow process from L-menthyl glyoxalate hydrate in a single solvent,...