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Tags: granule size distribution

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  1. Sam Henson

    https://cmkc.usp.org/members/1182

  2. Effects of Process and Design Parameters on Granule Size Distribution in a Continuous High Shear Granulation Process

    09 Jun 2023 | Contributor(s):: Meng, Wei, Oka, Sarang, Liu, Xue, Omer, Thamer, Ramachandran, Rohit, Muzzio, Fernando J.

    Wet granulation is widely used in the pharmaceutical industry. This advantageous technology is capable of enhancing compression and powder handling, decreasing ingredient segregation, and promoting blend and content uniformity. Currently, a high level of interest exists in the continuous version...

  3. Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model

    09 Jun 2023 | Contributor(s):: Liu, Huolong, Galbraith, Shaun C., Park, Seo-Young, Cha, Bumjoon, Huang, Zhuangrong, Meyer, Robert Frederick, Flamm, Matthew H., O'Connor, Thomas, Lee, Sau, Yoon, Seongkyu

    In this study, a novel three-compartmental population balance model (PBM) for a continuous twin screw wet granulation process is developed, combining the techniques of PBM and regression process modeling. The developed model links screw configuration, screw speed, and blend throughput with...