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Tags: gravimetric phase separation

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  1. Redesign of a Grignard-Based Active Pharmaceutical Ingredient (API) Batch Synthesis to a Flow Process for the Preparation of Melitracen HCl

    10 May 2024 | Contributor(s):: Pedersen, Michael J., Skovby, Tommy, Mealy, Michael J., Dam-Johansen, Kim, Kiil, Søren

    A Grignard-based batch process, for the preparation of Melitracen HCl, has been redesigned to fit a continuous reactor system. The Grignard addition is carried out at room temperature, with subsequent hydrolysis of the magnesium alkoxide intermediate followed by dehydration of the resulting...