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1. Development of a Continuous Flow Grignard Reaction to Manufacture a Key Intermediate of Ipatasertib

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   Contributor(s):: Kaldre, Dainis, Stocker, Severin, Linder, David, Reymond, Helena, Schuster, Andreas, Lamerz, Jens, Hildbrand, Stefan, Püntener, Kurt, Berry, Malcolm, Sedelmeier, Jörg

   This article outlines the development of a continuous flow process for the manufacture of a key intermediate of the active pharmaceutical ingredient ipatasertib for the treatment of metastatic castration-resistant prostate cancer and triple-negative metastatic breast cancer. The reaction sequence...

2. Operation Strategy Development for Grignard Reaction in a Continuous Stirred Tank Reactor

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   Contributor(s):: Wong, Sze-Wing, Changi, Shujauddin M., Shields, Richard, Bell, Willis, McGarvey, Bernard, Johnson, Martin D., Sun, Wei-Ming, Braden, Tim M., Kopach, Michael E., Spencer, Richard D., Flanagan, Gordon, Murray, Michael

   This paper presents a case study in establishing the operation space of a Grignard reaction in a continuous stirred tank reactor (CSTR). The operation space is the multivariate space with the boundary defined by the proven acceptable range of every CSTR process parameter such as flow rates and...

3. The Application of a Continuous Grignard Reaction in the Preparation of Fluconazole

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   Contributor(s):: Korwar, Sudha, Amir, Somi, Tosso, Perrer N., Desai, Bimbisar K., Kong, Caleb J., Fadnis, Swara, Telang, Nakul S., Ahmad, Saeed, Roper, Thomas D., Gupton, B. Frank

   The application of continuous methods in the synthesis of active pharmaceutical ingredients continues to receive significant attention in the academic as well as the industrial research communities. One of the major advantages of continuous methods is the ability to safely access kinetic synthons...